By W. Schramm, H. Krebs (auth.), Professor Dr. med. Inge Scharrer, Professor Dr. med. Wolfgang Schramm (eds.)
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Additional info for 33rd Hemophilia Symposium: Hamburg 2002
It will no longer be necessary to rely on »Rasputin-therapy« needed by the Russian tsarevitch Alexis. The J. W. Schoenlein Prize was awarded on November 08, 2002 for the 15th time to: Prof. Thierry VandenDriessche. He was born in 1965 in Ostende (Belgium). He is working in the Center of Transgene Technology and Gene Therapy of the University of Leuven and he is a visiting professor at the Free University in Brussels. He published 61 publications in well known peer-reviewed journals during the period of 1989–2002.
Vox Sang 1997; 72: 148–161 Azzazy HM, Highsmith WE, Jr. Phage display technology: clinical applications and recent innovations. Clin Biochem 2002; 35: 425–445 Stoilova-McPhie S, Villoutreix BO, Mertens K, Kemball-Cook G, Holzenburg A. 3-dimensional structure of membrane-bound coagulation factor VIII: modeling of the factor VIII heterodimer within a 3-dimensional density map derived by electron crystallography. Blood 2002; 99: 1215–1223 Rituximab – A new Treatment of Acquired Hemophilia A? M. Krause, C.
4). These results provide the proof of principle that random phage display libraries can be used for the mapping of epitopes in polyclonal antibody samples such as inhibitors from the plasma of haemophilia patients. The sensitivity of this method is currently evaluated on patient’s antibodies purified by an optimized procedure, in which the second chromatography step was modified. Furthermore, alterations in the phage display protocol such as subtractive panning strategies may be considered. Acknowledgements.