Download Asthma Treatment: A Multidisciplinary Approach by Peter K. Jeffery (auth.), D. Olivieri, P. J. Barnes, S. S. PDF

By Peter K. Jeffery (auth.), D. Olivieri, P. J. Barnes, S. S. Hurd, G. C. Folco (eds.)

From the 19-29 may well 1991 the NATO ASI path PAsthma remedy: A P Multidisciplinary technique was once held in Erice, at the rocky North West Coast of Sicily, dealing with the traditional Phoenician shore of the African Continent. Sixty NATO subsidized individuals strolling back from many alternative ecu nations - Nato individuals and non - attended the direction. certified researchers from Europe and the USA held broad lectures, brief conferences and small casual team discussions. Erice is a mystical position which pulls jointly humans from assorted backgrounds and cultures below her Mediterrean allure, recreating the traditional Greek openair dialogue surroundings. And so, through the 10 days accumulating, the huge willingness of the senior investigators and the laudable enthusiasm of the more youthful contributors was once inspired. the entire newest findings within the biology and the pharmacology of bronchial asthma have been mentioned, in the beginning in the back of closed doorways, to be unhurriedly endured alongside the alley methods of the "Cittadella della Scienza" , in Erice's small eating places, and on her abandoned shorelines. The texts gathered listed here are testimony to the top of the range of the investigators contributions in addition to their some distance achieving pursuits. i feel Director of this type of path will be adequatly happy via purely contemplating the keenness and excessive point involvement of each player. He couldn't were extra chuffed after having thought of the lawsuits summerizing the clinical content material of the meeting.

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96. K. G. J. Barnes, Bradykinin-induced bronchoconstriction in guinea-pig in vivo: role of neural mechanisms, J Pharmacol Exp Ther 253:1207-1212 (1990). 97. S. J. Barnes, Bradykinin induced bronchoconstriction : inhibition by nedocromil sodium and sodium cromoglycate, Br J Clin Pharmacol 270:8310-8360 (1989). 98. L. L. J. Woolcock, T. E. Sullivan, Substance P immunoreactive nerve fibres in airways from patients with and without asthma, Am Rev Respir Dis 139:A237 (1989). 99. K. J. Harmar, Nerve growth factor regulates expression of neuropeptide genes in sensory neurons, Nature 337:362-364 (1989).

A. B. Borson, Enkephalinase inhibitor potentiates substance P and electrically induced contraction in ferret trachea, J Appl Physiol 63:1401-1405 (1987). 76. K. J. A. Meldrum, and J. Maclagan, Facilitation of tachykinins of neurotransmission in guinea-pig pulmonary parasympathetic nerves, Br. J. Pharmacol. 97:274-280 (1989). 77. C. Martling, A. Saria, P. M. Lundberg, Capsaicin pretreatment inhibits vagal cholinergic and noncholinergic control of pulmonary mechanisms in guinea pig, Haunyn Schmiedeberg Arch ~ 325:343-348 (1984).

The bronchoconstrictor response is potentiated by epithelial removal and by phosphoramidon, suggesting that it is degraded by epithelial HEP. The bronchoconstrictor effect of CCK S is also potentiated in guinea pigs sensitised and exposed to inhaled allergen, possibly because allergen exposure reduces epithelial HEP function. CCK S acts directly on airway smooth muscle and is potently inhibited by the specific CCK antagonist L363,S51, indicating that CCKA-receptors (peripheral type) are involved.

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