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By Malcolm B. Segal

This booklet describes the most recent findings at the keep an eye on of the fluid setting of the attention and the mind. the attention is taken into account from its a number of interfaces. Carbonic anhydrase, which varieties a bridge among the attention and CSF, and the secretion and improvement of its drainage is reviewed. The blood-brain barrier is taken into account from the cerebral capillary, and up to date findings with homologous molecules refute the sooner stories with 'foreign' tracers. a last bankruptcy provides a desirable glimpse of the long run with an outline of the newest imaging options utilized in neurological prognosis.

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Barriers and Fluids of the Eye and Brain

This ebook describes the newest findings at the regulate of the fluid atmosphere of the attention and the mind. the attention is taken into account from its a number of interfaces. Carbonic anhydrase, which types a bridge among the attention and CSF, and the secretion and improvement of its drainage is reviewed. The blood-brain barrier is taken into account from the cerebral capillary, and up to date findings with homologous molecules refute the sooner experiences with 'foreign' tracers.

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Extra resources for Barriers and Fluids of the Eye and Brain

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The lucid descriptions of Guiseppina Raviola of the anatomy of the ciliary epithelium permitted the definition of gap junctions between the two cells and can explain the fact that both cells are at isopotential difference. That is, the two cells communicate and the ionic equilibrium is the same in both of them at least as regards the Cl- ion, tested with specific Cl- -sensitive microelectrodes. Although the rabbit does not show similar properties, it is a fact that the ciliary epithelium shows great species differences and investigators are forced to deduce the function of these layers as a composite of the information obtained in different animals.

Studies with radioactively labelled substances, such as amino acids and glucose, or their non-metabolizable analogues, revealed that even crystalloids that are not present in an excess in aqueous humour may also cross these barriers by a carrier-mediated, saturable process. , 1966). SIMILARITIES AND DIFFERENCES BETWEEN AQUEOUS HUMOUR AND CEREBROSPINAL FLUID The apparent similarities between CSF and aqueous humour were celebrated by the classic treatise entitled Physiology of Ocular and Cerebrospinal Fluid, one of the first among the many outstanding contributions of Hugh Davson (1956) to the scientific literature.

3, 283-297 Bito, L. , Davson, H. and Fenstermacher, J. (Eds) (1977). The Ocular and Cerebrospinal Fluids. Fogarty International Symposium. Academic Press, London Bito, L. , Davson, H. and Hollingsworth, J. R. (1976a). Facilitated transport of prostaglandins across the blood-cerebrospinal fluid and blood-brain barriers. J. Physiol. (London),256,273-285 Bito, L. , Murray, M. and Snider, N. (1966). The concentrations of free amino acids and other electrolytes in cerebrospinal fluid, in vivo dialysate of brain, and blood plasma of the dog.

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