Download Brain Hypothermia: Pathology, Pharmacology, and Treatment of by Nariyuki Hayashi (auth.), Nariyuki Hayashi M.D., Ph.D. PDF

By Nariyuki Hayashi (auth.), Nariyuki Hayashi M.D., Ph.D. (eds.)

Rapid development in expertise and its software to prognosis and tracking of mind tissue temperature and metabolism have led to advances within the remedy for seriously brain-injured sufferers and breakthroughs in figuring out the pathophysiology of mind harm. the most recent notion of mind hypothermia treatment clarifies objectives resembling mind thermal pooling, overlaying mind hypoxia linked to catecholamine surge, the metabolic shift from glucose to lipids, and selective radical harm of dopamine within the critical anxious procedure. This quantity explains the mechanism of mind harm and the way mind hypothermia therapy differs from different hypothermia treatment in 4 significant sections: mind harm Mechanism, Pathophysiology of Hypothermia, simple learn of Hypothermia therapy, and medical experiences of mind Hypothermia. The e-book is a helpful resource for practitioners and researchers in neurosurgery and neurology and in severe care and emergency medicine.

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Additional info for Brain Hypothermia: Pathology, Pharmacology, and Treatment of Severe Brain Injury

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Shiozaki T, Sugimoto H, Taneda M, Oda J, Tanaka H, Hiraide A, Shimazu T (1998) Selection of severely head injured patients for mild hypothermia therapy. J Neurosurg 89:206-211 56. Smith DG, Chen X-H, Pierce ES, Mcintosh TK (1997) Progressive atrophy and neuronal death for one year following brain trauma in the rat. J Neurotrauma 14:715-727 57. Smith SL, Hall ED (1996) Mild pre- and posttraumatic hypothermia attenuates blood-brain barrier damage following controlled cortical impact injury in the rat.

On the other hand, daily subcutaneous administration of testosterone (1 mg/l00 g body weight) gradually increased the HP in the blood, reaching a level three times that in the controls after 19 days of treatment. These results indicated that both hormones are effective in organisms as well as in cultured hepatocytes. 32 N. Kondo et aI. a. (%) 100 50 0 10-13 10-11 10-9 10-7 Thyroxine (M) b. -------------'r------------. 10-9 10-7 10-5 Testosterone (M) Effects of thyroxine (a) and testosterone (b) on the production of the protein complex HP in cultured hepatocytes from nonhibernating animals.

To quantify microglia proliferation, fine photographs were taken and the lectin-positive cells in the gray matter were counted by three people who did not have any information about the pictures. The average of the three counts was employed, and data were expressed as the number of cells per area of gray matter. Area of gray matter was calculated from the picture using NIH Image software. The existence of neuronal cells was recognized by microtubule-associated protein 2 (Amersham). Activation of microglia was detected by OX42 staining (Serotec, Japan) which has been reported to recognize activated immune cells [9].

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