By Ambrish Mithal M.D., Edward M. Brown M.D. (auth.), Naibedya Chattopadhyay, Edward M. Brown (eds.)
Calcium-Sensing Receptor presents an outline of assorted elements of the calcium receptor's biochemistry, body structure and pathophysiology that's appropriate either in the event you were operating within the box of Ca2+0-sensing in addition to people who are new to this self-discipline.
Calcium-Sensing Receptor is the 19th quantity released within the Endocrine Updates e-book sequence less than the sequence Editorship of Shlomo Melmed, MD.
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Extra info for Calcium-Sensing Receptor
For instance, the relative positions of 20 cysteines (17 in the N-terminal ECD, 1 each in the first and second predicted extracellular loops, and 1 in the fifth transmembrane span) are conserved in the CaR and mGluRs. A Cysrich region with nine highly conserved cysteines in a closely spaced (about 60-amino acids-long) sequence is present between the VFT domain and the TMD in the ECDs, in all of the members of family 3 except for GABABRI. The Venus fly trap and Cys-rich domains are not linked by disulfide bonds (26).
Measuring Ca2+j and IPs in a population of cells. THE CaR CAN BE REGULATED BY PKC It has been shown that high Ca2\-evoked suppression of PTH secretion and the concurrent increases in IPs and Ca2+j in parathyroid cells can be regulated negatively by activation of PKC (65-73). It has been suggested that such negative regulation is involved in the reduced responsiveness of adenomatous or hyperplastic parathyroid glands to Ca2+o , owing to an increase in membrane-associated PKC (74,75), although there is also reduced expression of the CaR in these pathological glands (76,77).
The side chains of disulfide bonded cysteine residues are shown as space filling, and the corresponding residue numbers are given. Lobes I and II, loops I to IV, and the amino (N)- and carboxy (C)-termini are labeled. The model was rendered using the programs MolScript and Raster3D and provided by Dr. Allen Spiegel. Besides the regions in the BCDs described above, the putative first and third intracellular loops (i 1 and i3) are significantly conserved in the CaR and mGluRs (49% and 69% identity, respectively).