By Stanislav Miertus, Giorgio Fassina
"Provides entire assurance of the present combinatorial methodologies and applied sciences hired for the layout, synthesis, and screening of molecular ""libraries."" good points tests of computer-assisted methods to guiding library synthesis. Designed to fulfill the call for to create, produce in excessive yield and purity, and speedily monitor large numbers of molecules."
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Extra info for Combinatorial Chemistry and Technology. Principles, Methods, and Applications
Me2 C(OOH)CH2 C(OO. )Me2 Me2 C(OOH)CH2 C(OO. )Me2 þ RH À! Me2 C(OOH)CH2 C(OOH)Me2 þ R. The further study of the mechanism of hydrocarbon oxidation presented another important peculiarity of these reactions, namely, their self-accelerated character. The principal explanation of this phenomenon was suggested by Semenov . He proposed that any active intermediate, formed as a result of hydrocarbon oxidation, slowly initiates new chains. The concentration of an intermediate (peroxide, aldehyde) increases during the initial stage of oxidation and this creates the increasing rate of chain initiation.
Kinetics and Mechanism of Cyclododecane Oxidation Directed to Hydroperoxide and Cyclododecanone. D. thesis, Moscow State University, Moscow, 1962, pp. 3–11 [in Russian]. GS Fisher, JS Stinson. Ind Eng Chem 47:1368, 1955. KI Ivanov, VK Savinova. Dokl AN SSSR 48:32, 1945. H Hock, A Neuwitz. Berichte 72:1562, 1939. KR Hargrave, AL Morris. J Chem Soc 89, 1956. H Hock, O Schrader. Brenst Chem 18:6, 1937. H Hock, O Schrader. Naturwiss 24:159, 1936. EH Farmer, A Sundralingam. J Chem Soc 121, 1942. R Criegee, H Pilz, H Flygare.
R. þ O2 À! RO2 . þ RH À! R. þ R. À! R. þ RO2 . À! RO2 . þ RO2 . À! r. RO2 . ROOH þ R. 1–1 atm higher than © 2005 by Taylor & Francis Group. 10À4 mol LÀ1. Because of this, the concentration of alkyl radicals is much lower than that of peroxyl radicals, and chains are terminated only by the reaction between two peroxyl radicals, while chain propagation is limited by the reaction RO2 þ RH. In the presence of the initiator I, initiation by the formed hydroperoxide is insignificant, so that the rate of initiation vi % ki[I].