Download Contemporary Topics in Immunobiology: Immunobiology of by Satvir S. Tevethia, Fred Rapp (auth.), Michael G. Hanna Jr., PDF

By Satvir S. Tevethia, Fred Rapp (auth.), Michael G. Hanna Jr., Fred Rapp (eds.)

It has lengthy been suspected, and lately proven, that there's an etiologic courting among a number of viruses and of course happening neoplasias. Virus precursors within the kind of nucleic acids or antigens have constantly been linked to sure neoplasias. although, the function of those virus-specified precursors in etiology continues to be vague. contemporary stories of virus-associated neo­ plasias have ended in advances in molecular innovations, that have yielded increas­ ingly delicate assays for detection of virus-specific nucleic acids, and that have enabled the disruption of virus debris with no concomitant loss in antigenicity of the elements. those methods have, in flip, led to molecular probes that permit extra definitive evaluate of the host reaction to its virus and to the tumor mobile with which the virus or its precursors are linked. reviews of the immune reaction and standing of the host have supplied very important informa­ tion approximately carcinogenesis and the instruments for seroepidemiological reviews of various cancers. those seroepidemiological reports have established that numerous human cancers, e. g. , Burkitt's lymphoma and nasopharyngeal carcinoma, are most likely virus-induced, and that antibodies which are diagnostic and prog­ nostic for those ailments are detectable. the realization that tom cat leukemia is a affliction transmitted horizontally by means of a scourge resulted basically from immunologi­ cal experiments.

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Extra info for Contemporary Topics in Immunobiology: Immunobiology of Oncogenic Viruses

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Along the same lines, the synthesis of T antigen was induced in permissive cells upon microinjection with RNA complementary to SV40 DNA transcribed in vitro. , 1974). Recently, evidence has been presented which more strongly suggests that T antigen is coded by the virus genome. It has been demonstrated that SV40 A gene is involved in the initiation of DNA synthesis in permissive cells (Tegtmeyer, 1972) and is involved in the maintenance of the transformed-cell phenotype. Cells transformed by the tsA mutants show a transformed cell phenotype at the permissive temperature.

This immunological unresponsiveness to T antigen was shown to be due to the immunological tolerance to T antigen which could be terminated by tumor resection and reimmunization with tumor homogenate in Freund's complete adjuvant. The antibodies to T antigen in hamsters have also been shown to develop in the absence of a visible tumor (Diamandopoulos and McLane, 1974). , 1967). The synthesis of antibodies to T antigen in a semipermissive host (rabbit) was demonstrated to depend upon the dose of infecting virus.

Rapp and Duff (1973) demonstrated that HSV-2 tumor cells have the capacity to metastasize to lungs. The number of lung metastases was actually enhanced rather than inhibited by immunization of the animals with HSV prior to challenge with HSV-2-transformed cells. The development of metastases in the lungs of tumor-bearing hamsters was inhibited by prior immunization of animals with papovavirus SV40, thus indicating that the animals might be responding to antigens common to SV40- and HSVtransformed cells which might be embryonic in nature.

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