Download Contemporary Topics in Immunobiology: Volume 8 by J. F. A. P. Miller (auth.), Noel L. Warner, Max D. Cooper, PDF

By J. F. A. P. Miller (auth.), Noel L. Warner, Max D. Cooper, M. G. Hanna Jr. (eds.)

In this present quantity of up to date issues in Immunobiology now we have selected to proceed with the multiple-theme procedure that was once constructed in Volumes 1, three, and five of this sequence. Immunobiology nonetheless indicates little signal of lowering its energetic development expense, yet particularly is constant to develop its diversity of pursuits and functions, rather as new recommendations and techniques are tailored from different fields of scientific learn. This current quantity displays either numerous of the extra classical components of immunology now addressed within the mild of up to date immunology, and a number of other more moderen instructions which were taken in different fields. the overall topic of T-cell heterogeneity and features of T-cell subpop­ ulations is addressed in Chapters 1 and a pair of. the aptitude position of genes of the main histocompatibility advanced in controlling the immune services of T lymphocytes nonetheless is still a big unresolved factor in immunogenetics, and the present prestige of this challenge is excellently reviewed by way of J. F. A. P. Miller. The additional elucidation of useful subpopulations of human T lymphocytes has been relatively hampered through the shortcoming of obtainable markers for personality­ izing and separating such sUbpopulations. an incredible step during this path has been made by means of L. Moretta, M. Ferrarini, and M. D. Cooper, who overview their ex­ perience with Fc-receptor-bearing human T-Iymphocyte populations.

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Extra resources for Contemporary Topics in Immunobiology: Volume 8

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G cells are destined to serve a suppressor function. , 1977). G cells may be subdivided further into distinct subsets that have very specialized functional capabilities. An increased propor- Characterization of Human T-Cell Subpopulations 41 tion of T. G cells, therefore, may not necessarily give a precise indication of an excess of suppressor T-cell numbers or of suppressor activity. The mechanism by which T. G cells exert their suppressive function is not yet totally understood. However, some aspects of the problem deserve comment.

The proliferative response was determined by incorporation of 3H-thymidine and compared with that of unfractionated T cells. Almost identical dose response curves to Con A were observed for all of the populations tested. On the contrary, consistent differences were detected in the PHA response. PHA elicited a response of T'M cells only at concentrations higher than those capable of inducing stimulation in unfractionated T cells. Although T'G cells responded at all of the PHA concentrations tested, their response was consistently lower than that of the un fractionated T cells.

F. A. , 1975, A radioisotopic method to measure delayed type hypersensitivity in the mouse. I. Studies in sensitized and normal mice,lnt. Arch. Allergy Appl. Immunol. 49:670. Vadas, M. , Miller, 1. F. A. , McKenzie, I. F. , Chism, S. , Shen, F. , Boyse, E. , 1976, Ly and Ia antigen phenotypes of T cells involved in delayed type hypersensitivity and in suppression,J. Exp. Med. 144:10. Vadas, M. , Miller, J. F. A. , 1977, Regulation by the H·2 gene complex of delayed-type hypersensitivity, Immunogenetics 4: 137.

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