By Thomas M. Herndon, George C. Tsokos (auth.), Priv.-Doz. Dr. Annegret Kuhn, Prof. Dr. Percy Lehmann, Prof. Dr. Dr. H.C. Thomas Ruzicka (eds.)
Lupus erythematosus is a prolonged inflammatory autoimmune disorder characterised by means of a large spectrum of manifestations with a variable evolution. there was a long-standing want for a booklet with a unifying proposal at the cutaneous manifestations of this sickness. The publication relies on multidisciplinary wisdom and is written by way of major clinicians and scientists. It offers not just a entire description of the immense number of cutaneous abnormalities but additionally a synthesis of the connection among cutaneous and systemic adjustments, together with chapters on category and scientific features, pathogenesis and pathologic gains, and therapy and administration of lupus erythematosus. In precis, the booklet is a vital source for clinicians and scientists operating within the box of autoimmune diseases.
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Extra info for Cutaneous Lupus Erythematosus
Mice were sensitized with fluorescein isothiocyanate after UVB treatment. The T cells cloned from these mice were phenotypically analyzed as CD4+, CD8–, TCR-α/β+, MHC-restricted T cells specific for the fluorescein isothiocyanate antigen. They secreted IL-10 but not IL-4 or interferon-γ, whereas cells from nonirradiated control animals produced high amounts of interferon-γ and little IL-4 and IL-10 (Shreedhar et al. 1998b). The cytokine pattern Photoimmunology 25 of the UVB-induced cells was related but not identical to that of T regulatory 1 cells; thus, the authors designated these cells as T regulatory 2-type cells.
This work was supported by the German Research Association (DFG) project BE 1580/2–3, SFB 293, IZKF grant Lo2/065/04, and a European Community Grant QLK4-CT-2001-00115. References Aberer W, Schuler G, Stingl G, Hönigsmann H, Wolff K (1981) Ultraviolet light depletes surface markers of Langerhans cells. J Invest Dermatol 76:202–210 Aberer W, Stingl G, Stingl-Gazze LA, Wolff K (1982) Langerhans cells as stimulator cells in the murine primary epidermal cell-lymphocyte reaction: alteration by UV-B irradiation.
It is noteworthy that cutaneous manifestations account for 4 of the 11 revised criteria for the classification of SLE. In the present chapter, we present the most important data regarding the incidence and prevalence of LE in the general population; the epidemiology of the main clinical and immunologic features of LE, with special emphasis on the more relevant cutaneous manifestations; overall information on the patterns of disease expression in specific subsets; and studies on mortality in LE.