Download Solid-Phase Organic Syntheses by Anthony W. Czarnik PDF

By Anthony W. Czarnik

The speedy growth of combinatorial chemistry has renewed curiosity in solid-phase natural synthesis, a mode that lends itself good to making and screening huge numbers of lead compounds. Solid-Phase natural Syntheses, quantity 1 is the 1st quantity in a chain that may be up to date every year, filling a spot within the current chemical literature. offering info formerly unavailable from a unmarried source, this sequence is devoted to delivering researchers within the box with confirmed and established tools for the solid-phase synthesis of fascinating and biologically correct molecules.
Solid-phase tools will almost regularly be invented for program in combinatorial natural synthesis. to fulfill those particular wishes, Solid-Phase natural Syntheses, quantity 1 specializes in a unmarried kind of man made transformation finished on reliable aid, and exhibits how systems are optimized to paintings with a structurally-wide number of reagents. Written by means of famous leaders within the box who assessment and try all chemical protocols earlier than booklet, natural alterations are equipped by means of form of compound synthesized and response type.
For the 1st time, experimental info for confirmed solid-phase artificial molecules are gathered in one, beneficial source. Solid-Phase natural Syntheses, quantity 1 presents combinatorial chemists and researchers in natural chemistry and medicinal chemistry with the instruments and descriptive protocols to accomplish syntheses of wanted compounds utilizing a number of reliable helps and reagents.

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66). Compound C1. 48). Compound C2. 49). Compound C3. 51). Compound C4. 41). Compound C5. 51). Compound C6. 61). Compound D1. 51). Appendix 53 Compound D2. 51). Compound D3. 53). Compound D4. 44). Compound D5. 54). Compound D6. 64). Compound E1. 60). Compound E2. 61). Compound E3. 63). Compound E4. 54). Compound E5. 64). Compound E6. 74).

9. ; Ralph, A. , J. Org. Chem. 1997, 62, 6090. 60 (s, 1H, NH) ppm. MS/EI (C19H28N4O3) calculated: 360, observed: 383 (þNa þ ). 41 (s, 1H, NH) ppm. MS/EI (C20H30N4O4) calculated: 390; observed: 413 (þNa þ ). 41 (s, 1H, NH) ppm. MS/EI (C19H27N5O5) calculated: 405; observed: 428 (þNa þ ). 64 (s, 1H, NH) ppm. MS/EI (C16H24N4O3) calculated: 320; observed: 343 (þNa þ ). 44 (s, 1H, NH) ppm. MS/EI (C17H26N4O4) calculated: 350, observed: 373 (þNa þ ). 44 (s, 1H, NH) ppm. MS/EI (C16H23N5O5) calculated: 365, observed: 388 (þNa þ ).

Each resin was filtered and rinsed with methylene chloride (2 mL). The filtrate was concentrated under a stream of nitrogen gas to a brown residue. This material was dissolved in acetonitrile (4 mL), and the product was concentrated again under a stream of nitrogen. This procedure was repeated two more times using methanol 48 Solid-Phase Mannich Reactions of a Resin-Immobilized Alkyne (4 mL) to dissolve the residue (note 3). 2). The products were typically obtained as brown glassy solids (note 4).

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